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Abstract
Introduction. At present, the use of non-invasive tools for routine diagnosis of GERD, which include questionnaires, remains relevant. The most promising in this regard is the GerdQ questionnaire. Purpose: to study the diagnostic value of the GerdQ questionnaire on the possibilities of diagnosing GERD based on the comparison of the results of the questionnaire with the results of 24-hour intraluminal esophageal-impedance-pH monitoring in Ukraine. Materials and methods: 28 patients underwent 24-hours esophageal-impedance-pH monitoring after completing the GerdQ questionnaire. The results of the instrumental method for the diagnosis of GERD were compared with the results of the GerdQ questionnaire. Results and discussion: a statistically significant correlation of high strength between the frequency of acid reflux episodes (pH <4) and the sum of GerdQ questionnaire scores — 0.796, the episode frequency of all liquid refluxes and the sum of GerdQ questionnaire scores — 0.730, the percentage of time with 4 p in the esophagus and the sum of the scores of the GerdQ questionnaire — 0.793. According to the analysis of the ROC curve, the best cut-off point is a total score > 7. The sensitivity of the questionnaire was 78.7% (95% CI, 49-95), specificity — 92.9% (95% CI, 66-99). AUC=0.95±0.04; p<0.0001. According to the model classification characteristics, a model with an AUC (area under the ROC curve) greater than 0.9 is characterized as an excellent model. Conclusions: it is optimal to use the GerdQ questionnaire for the diagnosis of GERD by primary care physicians in everyday practice to decide on the possibility of prescribing therapy «ex juvantibus», or the need for instrumental methods of examination (upper endoscopy, esophago-pH-monitoring, esophago-p- monitoring), as it showed a reliable, high degree of correlation between the sum of the questionnaire scores and key indicators of daily impedance-pH monitoring (episodes of acid reflux, episodes of liquid reflux, % time with pH in the esophagus <4).
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