Androgen deficiency in terms of cardiovascular disease risk in men with hypothyroidism

Abstract

Introduction. Cardiovascular disease continues to be one of the most common medical problems worldwide. One of the reasons for the risk of occurrence and progression of cardiovascular diseases is age-related androgen deficiency. The presence of hypothyroidism in men with age-related hypogonadism can be a trigger in the occurrence of cardiac problems. That is why the search for risk factors for the occurrence and progression of these diseases is still relevant. Target. To assess the clinical signs of age-related androgen deficiency and their relationship with risk factors for cardiovascular disease in men with hypothyroidism. Materials and methods. 84 people were examined, including 38 people with hypothyroidism and agerelated androgen deficiency, 46 patients with hypothyroidism and normal testosterone levels. The control group was formed by 20 people without hypothyroidism. The age of all subjects ranged from 42 to 60 years. The state of lipid and carbohydrate metabolism was determined, the presence and type of obesity, the level of depression were assessed, and daytime monitoring of blood pressure was performed. Results. A decrease in testosterone levels in men with hypothyroidism is accompanied by an increase in the incidence of abdominal obesity, elevated triglyceride and glucose levels, and is associated with subclinical depression. In men with hypothyroidism and androgen deficiency, the average values of blood pressure during the daytime significantly exceed those in patients with hypothyroidism and normal testosterone levels. Conclusions. The presence of age-related androgen deficiency has a negative impact on risk factors for cardiovascular disease in men with hypothyroidism.