The dynamics of activity liver enzymes at children’s serum in the case of chronic and exacerbative granulating apical periodontitis in permanent teeth under the comprehensive treatment

Abstract

Introduction. The oral cavity is the beginning of the digestive system, and its connection with other organs of this system is obvious. That is why dental diseases can cause or worsen the course of pathological processes of the organs of the gastrointestinal tract. An unsanitary oral cavity, especially in a child, can be a risk factor for general somatic disease. Рurpose. To investigate the activity of liver enzymes in the blood serum of children with chronic and acute granulating periodontitis, immediately after local treatment and a course of the proposed general therapy lasting 1 and 3 months. Material and methods. The study involved 63 children, patients with granulating periodontitis permanent teeth, age 12-18 years and determined the activity of liver enzymes: arginase, cholinesterase, aspartate aminotransferase (AST), alanine aminotransferase (ALT) of serum. Results. A marked increased activity of arginase and decrease in cholinesterase activity convincing in the case of chronic granulating apical periodontitis of permanent teeth and in the case of the exacerbation of this pathological process. It was also found a significant increase of ALT and AST parameters in case of the exacerbation of disease. Our proposed local treatment of chronic granulating periodontitis and exacerbation of chronic granulating periodontitis of permanent teeth in children contributed to significant changes in the activity of all studied liver enzymes. Сonclusions. The results obtained suggests that periodontal pathology affects the functional activity of the liver cells. The results of the study of the level of activity of serum enzymes in children with chronic granulating periodontitis and an exacerbation of chronic granulating periodontitis, before and at different times after treatment, showed that local therapy practically does not affect these indicators. The dynamics of changes in the activity level of liver enzymes in the blood serum of children with chronic granulating periodontitis, before and after therapy, proved that the complex treatment developed by us has a pronounced positive effect on the regulation of these indicators, especially during exacerbation of the pathological process.