Morphological and functional changes of the liver in experimental diabetes mellitus on the 56th day of the experiment

Abstract

Diabetes mellitus (DM) is one of the most common diseases of the endocrine system. Despite the fact that a significant number of scientific researches are devoted to the issues of pathomorphogenesis of diabetes and its management, this disease still remains a significant medical and social problem. The main role in the progression of diabetes is attributed to chronic hyperglycemia and the lack of its compensation, which has a significant effect on the pathogenesis of late complications. Therefore, it is currently important to establish specific characteristics of morphofunctional changes of liver in rats of different ages with streptozotocin-induced diabetes mellitus. The morphometric study of the liver in rats aged 3 months light-optical and ultrastructural studies of cells shows that there are the largest number of young (dark) hepatocytes, which are characterized by: dense cytoplasm, large number of young mitochondria, sufficient
number of glycogen granules, hypertrophied granular endoplasmic cells. We have observed glycogen inclusions in light and dark hepatocytes, as a manifestation of compensatoryreducing processes. Male Wistar rats aged 3 months (with the weight of 80-100 g), were involved in the study
and divided into 2 groups. Group I consisted of 10 animals where experimental diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (SIGMA Chemical (USA), previously diluted in 0.1 M of citrate buffer at pH 4.5: were given 7 mg/100 g of the body weight, Group II (control) consisted of 10 animals which