Correction of dysbiosis of the colon and its influence on the dynamics of free amino acids levels in blood serum in patients with chronic pancreatitis and type 2 diabetes

Abstract

Introduction. Intestinal dysbiosis (DB) often occurs in diseases of the digestive tract, in particular in chronic pancreatitis (CP). The aim of the study was investigate the effectiveness of various DB correction and its effect on the dynamics of serum free amino acids (SFAA) in patients with CP and type 2 diabetes mellitus (DM). Materials and methods of research. 82 patients with CP and type 2 diabetes were examined. All examined patients underwent general clinical studies, feces for dysbiosis, as well as determination of the level of SFAA. Patients with CP and type 2 diabetes are divided into 2 groups depending on the method of correction of DB. Results and discussion. Prescribed therapy was effective in both groups of examined patients with CP and type 2 diabetes on the severity of DB. Normalization of the intestinal microbiota in patients with CP and type 2 diabetes was accompanied by positive dynamics in the levels of SFAA. A decrease in the levels of methionine, valine, cysteine in patients of both study groups was found. Attention is drawn to the more pronounced positive dynamics in the levels of such amino acids as tryptophan, tyrosine, phenylalanine, asparagine (p<0.01), mainly in patients of group II. Conclusions. In patients with CP and type 2 diabetes, DB of mainly III and II degrees were found, which is accompanied by a violation of the levels of SFAA in these patients. Complex therapy with Bacillus coagulans and vitamin B9, B12 in combination with B. infantis 35624 in patients with CP and type 2 diabetes is an effective means of normalizing of DB, which, in turn, is accompanied by positive dynamics in the levels of SFAA (decrease of methionine, valine, cysteine and increased levels of tryptophan, tyrosine, phenylalanine).