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Abstract
Purpose: to investigate changes in resistin and its relationship with endogenous intoxication and immunoinflammatory syndrome in patients with alcoholic liver cirrhosis (ALC) in combination with obesity. Materials and methods. The 380 patients with diagnosed ALC were examined, among which there were 230 patients with ALC in combination with obesity (I group of classes A, B and C according to Child — Turcott — Pugh) and 150 patients with ALC without obesity (II group of classes A, B and C after Child — Turcott — Pugh). The level of resistin in the blood was determined by enzyme immunoassay. The degree of endogenous intoxication was determined by the leukocyte intoxication index (LII) and the sorption capacity of erythrocytes (SCE). The level of the inflammatory process was assessed by the content of tumor necrosis factor alpha (TNF-α). Results and discussion. The increase of resistin and TNF-α content were revealed in the blood of ALC patients with obesity with increasing decompensation, which was accompanied by more pronounced manifestations of
endogenous intoxication with increasing levels of LII and SCE. Correlation analysis between resistin levels and Child — Turcott — Pugh scores and the MELD index showed a deeper сorrelation in group I with increasing decompensation. In particular, between the level of resistin and the Child — Turcott — Pugh index the correlation index was r=+0.52, r=+0.79, r=+0.84 and between the level of resistin and MELD was r=+0.56, r=+0.72, r=+0.78 for classes A, B, C respectively. In patients with ALC in combination with obesity in classes A, B and C the direct correlations have been established between the level of resistin and TNF-α (r1=+0.62, r2=+0.74, r3=+0.83), SCE (r1=+0.59, r2=+0.73, r3=+0.78) and LII (r1=+0.63, r2=+0.70, r3=+0.76). Conclusions. The higher level of resistin in the blood, the higher degree of endogenous intoxication and systemic inflammation, which increased with increasing Child-Turcott-Pugh class were ascertained in the presence of concomitant obesity in patients with ALC. There is a direct correlation between Child — Turcott — Pugh and MELD indices and resistin levels, as well as between resistin levels and SCE, LII and TNF-α levels in ALC patients in combination with obesity.
References
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