The role of SOD2 polymorphism in patients with hypertension and subclinical hypothyroidism

Abstract

Arterial hypertension (AH) and subclinical hypothyroidism (SH) have common risk factors and pathogenetic mechanisms, so their combined course may lead to the appearance or deepening of cardiovascular disorders. Alteration of oxidative stress processes is considered as one of the key mechanisms for the development of both diseases. Superoxide dismutase 2 (SOD2) is one of the most important enzymes of antioxidant protection. Therefore, understanding the role of polymorphic variants of the SOD2 gene in the formation of metabolic disorders may be effective in preventing complications in patients with AH and SH. The aim of the study was to investigate the association between the polymorphism rs4880 SOD2 gene and cardiometabolic parameters and markers of oxidative state and inflammatory processes in patients with AH and SH of different cardiovascular risk. Materials and methods. The study included 127 patients with a median age of 48.3 [40.7; 54.8] years (women 52.8%), of whom the control group consisted of 30 relatively healthy volunteers, the comparison group included 45 patients with hypertension; the main group consisted of 52 patients with AH and SH. Results. There were fewer carriers of the CT genotype and more TT genotypes among patients with AH and SH compared to other groups. No differences in total SOD protein concentration were found depending on the polymorphic variant of SOD2. The effect of the T allele on the level of low-density lipoprotein cholesterol (LDL-C) was revealed (p=0.032) in patients with AH and SH. Patients with AH and SH with the CT genotype had significantly (p>0.05) lower LDL-C levels compared with the CC genotype, lower creatinine, but higher diastolic blood pressure and waist circumference compared with the TT genotype. Conclusions. The rs4880 SOD2 polymorphism is associated with cardiometabolic disorders in patients with combined course of AH and SH. Presumably, carriers of the TT genotype in this category of patients form a risk group with regard to the unfavorable cardiometabolic profile and cardiovascular prognosis. Identification of a polymorphic variant of the rs4880 SOD2 gene may be effective for the prevention of cardiovascular complications in patients with AH and SH.